Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.58 |
| ▸ | PLAT | P00750 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 5/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | THRA | P10827 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19142120 | 0.87 | CHRNB2 (0.64) | TRPV1NR1H4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9826537 | 0.83 | ALOX15 (0.72) | TRPV1PLK1PLK3ALOX15THRA | |
| SCHEMBL543491 | 0.83 | RARB (0.57) | PLK1PLK3 | |
| SCHEMBL29229439 | 0.79 | TRPV1 (0.56) | TRPV1PLK1PLK3SPHK1ALOX15 | |
| SCHEMBL7160756 | 0.78 | ABCG2 (0.59) | PLK1PLK3THRATHRB | |
| SCHEMBL9827917 | 0.78 | ACLY (0.60) | ALOX15THRATHRB | |
| SCHEMBL4160309 | 0.77 | HNF4A (0.59) | — | |
| SCHEMBL13181181 | 0.77 | TRPV1 (0.81) | TRPV1PLK1PLK3THRATHRB | |
| SCHEMBL19141806 | 0.77 | CHRNB2 (0.64) | PLAUPLATNR1H4ALOX15CHRNB2 | |
| SCHEMBL7190666 | 0.76 | TRPV1 (0.61) | TRPV1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |