Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982894 | 0.92 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL2789208 | 0.85 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL985642 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL3602720 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL29158183 | 0.77 | GPBAR1 (0.59) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL29158182 | 0.77 | GPBAR1 (0.59) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL25890038 | 0.76 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL12640683 | 0.76 | CYP19A1 (0.62) | ALDH1A1SMN1; SMN2KMT2AGAACYP1A2 | |
| SCHEMBL982063 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL2778056 | 0.74 | NR4A2 (0.47) | ALDH1A1KMT2AMEN1GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257545-B1 | PYRROLIDINYL DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |
| US-20110021556-A1 | PYRROLIDINYL DERIVATIVES AND USES THEREOF | HOFFMAN-LA ROCHE, INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021556-A1 | PYRROLIDINYL DERIVATIVES AND USES THEREOF | SLC6A3, MAOB, TPH2 | ALDH1A1 837/4885SMN1; SMN2 2324/4885KMT2A 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.