Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.66 |
| ▸ | MYLK | Q15746 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 3/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.47 |
| ▸ | GLI1 | P08151 | 2/20 | 0.47 |
| ▸ | GLI2 | P10070 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263673 | 0.86 | ROCK2 (0.87) | ROCK2MYLKPDGFRBPRKCAMAP3K5 | |
| SCHEMBL9263506 | 0.81 | ROCK2 (0.78) | ROCK2MYLKPDGFRBPRKCAMAP3K5 | |
| SCHEMBL9260091 | 0.81 | ROCK2 (0.78) | ROCK2MYLKPDGFRBPRKCAMAP3K5 | |
| SCHEMBL9826964 | 0.79 | MYLK (0.59) | ROCK2MYLKPDGFRBPRKCAMAP3K5 | |
| SCHEMBL9265479 | 0.74 | MYLK (0.71) | ROCK2MYLKPDGFRBPRKCAPRKCQ | |
| SCHEMBL9260508 | 0.74 | MYLK (0.76) | ROCK2MYLKPDGFRBPRKCAPRKCQ | |
| SCHEMBL9545490 | 0.71 | ROCK2 (0.88) | ROCK2PRKCAMAP3K5PRKCQPRKCD | |
| SCHEMBL14494184 | 0.70 | MAP3K9 (0.72) | ROCK2MYLKPDGFRBPRKCAMAP3K5 | |
| Gw296115X SCHEMBL8120713 | 0.69 | PDGFRB (1.00) | ROCK2PDGFRBPRKCAPRKCQPRKCD | |
| Gw296115X SCHEMBL31281911 | 0.69 | PDGFRB (1.00) | ROCK2PDGFRBPRKCAPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0370236-B1 | INDOLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-12-27 | — | — | EP | disclosed |
| EP-0370236-A1 | Indolocarbazole derivatives, processes for their preparation and their use as medicaments | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | disclosed |