Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527760 | 0.86 | CDC25B (0.55) | HSD17B10MAPTPLK1KDM4EALDH1A1 | |
| SCHEMBL30742694 | 0.82 | PLK1 (0.56) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL1027499 | 0.82 | HSD17B10 (0.57) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL4099121 | 0.82 | PLK1 (0.56) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL5770092 | 0.81 | PLK1 (0.45) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL9245114 | 0.81 | PLK1 (0.45) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL70429 | 0.81 | LMNA (0.59) | HSD17B10MAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL10390867 | 0.79 | KDM4E (0.41) | HSD17B10MAPTGAATSHRMAPK1 | |
| SCHEMBL15565938 | 0.79 | PDE5A (0.42) | KDM4EALDH1A1 | |
| SCHEMBL15565940 | 0.79 | PDE5A (0.42) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199646-B1 | PROCESS FOR PREPARING 6-ALKOXY-5-TRIFLUOROMETHYL-1-NAPHTOIC ACIDS AND NOVEL 1-CYANO-NAPHTALENE INTERMEDIATES | ETHYL CORPORATION (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4946987-A | Treatment for complications of diabetes | AYERST, MCKENNA & HARRISON, INC. (CA) | 1990-08-07 | — | — | US | disclosed |
| US-4739100-A | Process for preparing 6-(lower) alkoxy-1-naphthoic acids and the corresponding esters and use of this process for preparing 6-(lower) alkoxy-5-halo-1-naphthoic acids and the corresponding esters | DELALANDE S.A. (FR) | 1988-04-19 | — | — | US | disclosed |
| US-4705882-A | ALDOSE REDUCTASE INHIBITORS, ANTIDIABETIC AGENTS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1987-11-10 | — | — | US | disclosed |
| EP-0199646-A2 | Process for preparing 6-alkoxy-5-trifluoromethyl-1-naphtoic acids and novel 1-cyano-naphtalene intermediates | ETHYL CORPORATION (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4600724-A | ALDOSE REDUCTASE INHIBITOR, DIABETES | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-07-15 | — | — | US | disclosed |
| US-4590010-A | Substituted naphthoic acid process | ETHYL CORPORATION (US) | 1986-05-20 | — | — | US | disclosed |
| US-4568693-A | ANTIDIATBETIC AGENTS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-02-04 | — | — | US | disclosed |
| US-4562286-A | Process for preparing methoxytrifluoromethylnaphthoic acid from dimethylnaphthalene | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-31 | — | — | US | disclosed |
| US-4560794-A | Process for preparing methoxytrifluoromethylnaphthoic acid from methylnaphthoic acid | OCCIDENTAL CHEMICAL CORPORATION (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0059596-B1 | N-NAPHTHOYLGLYCINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-04-24 | — | — | EP | disclosed |
| US-4499310-A | 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its preparation and ethers thereof | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-02-12 | — | — | US | disclosed |
| US-4439617-A | TREATING DIABETES, ENZYME INHIBITOR | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-03-27 | — | — | US | disclosed |
| US-4408077-A | 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes | AYERST, MCKEENA & HARRISON, INC. (CA) | 1983-10-04 | — | — | US | disclosed |
| US-4391825-A | ALDOSE REDUCTASE INHIBITORS, FOR TREATING DIABETIC COMPLICATIONS | AYERST, MCKENNA & HARRISON INC. (CA) | 1983-07-05 | — | — | US | disclosed |
| EP-0059596-A1 | N-Naphthoylglycine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-09-08 | — | — | EP | disclosed |