Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30742694 | 1.00 | PLK1 (0.56) | PLK1ESR1ESR2CDC25BGAA | |
| SCHEMBL14999028 | 0.89 | ESR1 (0.54) | PLK1ESR1ESR2CDC25BGAA | |
| SCHEMBL24101354 | 0.89 | PLK1 (0.70) | PLK1CDC25BGAATSHRHSD17B10 | |
| SCHEMBL70429 | 0.88 | LMNA (0.59) | TSHRHSD17B10MAPTALDH1A1KDM4E | |
| SCHEMBL7558028 | 0.84 | CDC25B (0.69) | PLK1CDC25BHSD17B10MAPTHPGDS | |
| SCHEMBL13328998 | 0.84 | KDM4E (0.57) | ESR1ESR2GAATSHRHSD17B10 | |
| SCHEMBL4103770 | 0.83 | CDC25B (0.68) | PLK1ESR1ESR2CDC25BGAA | |
| SCHEMBL835587 | 0.83 | MAPT (0.58) | PLK1ESR1ESR2CDC25BGAA | |
| SCHEMBL9827014 | 0.82 | HSD17B10 (0.47) | PLK1ESR1ESR2CDC25BGAA | |
| SCHEMBL5770092 | 0.82 | PLK1 (0.45) | PLK1ESR1ESR2CDC25BGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478358-B | A kind of organic photoelectrical material containing spirane structure and its application | 中节能万润股份有限公司 | 2018-08-28 | — | — | CN | disclosed |
| CN-106478358-A | A kind of organic photoelectrical material containing spirane structure and its application | 中节能万润股份有限公司 | 2017-03-08 | — | — | CN | disclosed |
| US-20100203326-A1 | AROMATIC LIQUID-CRYSTALLINE POLYESTER AMIDE COPOLYMER, PREPREG INCLUDING THE SAME, PREPREG LAMINATE INCLUDING THE PREPREG, METAL FILM LAMINATE INCLUDING THE PREPREG, AND PRINTED WIRING BOARD INCLUDING THE PREPREG | SAMSUNG FINE CHEMICALS CO., LTD. (KR) | 2010-08-12 | — | — | US | disclosed |
| US-20090221645-A1 | Dihydroimidazothiazole Derivatives | PROSIDION LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090221645-A1 | Dihydroimidazothiazole Derivatives | PROSIDION LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090221645-A1 | Dihydroimidazothiazole Derivatives | PROSIDION LIMITED (GB) | 2009-09-03 | — | — | US | disclosed |
| CN-101155817-A | Dihydroimidazothiazole derivatives | PROSIDION LTD (GB) | 2008-04-02 | — | — | CN | disclosed |
| EP-0175450-B1 | AN INTERPHENYLENE-CARBACYCLIN COMPOUND | THE UPJOHN COMPANY (US) | 1989-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221645-A1 | Dihydroimidazothiazole Derivatives | TPH1, HTR3B, HTR1A | PLK1 3361/4885ESR1 975/4885ESR2 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.