Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.72 |
| ▸ | PLG | P00747 | 3/20 | 0.62 |
| ▸ | KLK1 | P06870 | 2/20 | 0.62 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.55 |
| ▸ | PLAT | P00750 | 1/20 | 0.55 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10386151 | 0.87 | ALOX15 (0.71) | ALOX15PLGF2F10PLAU | |
| SCHEMBL9826705 | 0.86 | ALOX15 (0.69) | ALOX15KLKB1GAAMAPTMEN1 | |
| SCHEMBL9826365 | 0.84 | ALOX15 (1.00) | ALOX15PLGKLK1KLK6F2 | |
| SCHEMBL11594657 | 0.79 | NPC1 (0.66) | ALOX15PLGKLK1KLK6F2 | |
| SCHEMBL21274699 | 0.77 | PLG (1.00) | ALOX15PLGKLK1KLK6F2 | |
| SCHEMBL11479890 | 0.77 | NR1H4 (0.58) | ALOX15EPHX2MAPTMEN1KMT2A | |
| SCHEMBL9827298 | 0.77 | KLKB1 (0.62) | ALOX15PLGKLK1KLK6KLKB1 | |
| SCHEMBL14363176 | 0.76 | PLAU (0.60) | F2F10PLAUPLATMAPT | |
| Hydrochloric Acid SCHEMBL22799450 | 0.76 | PLG (1.00) | ALOX15PLGKLK1KLK6F2 | |
| SCHEMBL9826824 | 0.76 | ALOX15 (0.75) | ALOX15PLGKLK1KLK6F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |