Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827220 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1HPGDADRA1AHSD17B10 | |
| SCHEMBL9828688 | 0.81 | MEN1 (0.49) | MAPK1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9827507 | 0.77 | PDE3A (0.44) | CDK1CDK2CCNB1CCNE1MAPK1 | |
| SCHEMBL10648662 | 0.76 | PDE3A (0.46) | CDK1CDK2CCNB1CCNE1MAPK1 | |
| SCHEMBL9827521 | 0.75 | KDM4E (0.32) | CDK1CDK2CCNB1CCNA2CCNA1 | |
| SCHEMBL10436189 | 0.71 | MEN1 (0.49) | MAPK1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9917839 | 0.71 | CDK1 (0.51) | CDK1CDK2CCNB1CCNE1CCNA2 | |
| SCHEMBL9584007 | 0.70 | HDAC1 (0.36) | CDK1CDK2CCNB1CCNE1CCNA2 | |
| SCHEMBL9827056 | 0.69 | BLM (0.53) | MAPK1ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL21562148 | 0.68 | CDK1 (0.49) | CDK1CDK2CCNB1CCNE1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217207-B1 | 2-AMINO PURINES SUBSTITUTED IN POSITIONS 6 AND 9, THEIR USE, MEDICAMENTS CONTAINING THESE PURINES AND PROCESSES FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-04-10 | — | — | EP | claimed |
| EP-0400686-A1 | 2-Amino-9-[1,3bis-(isopropoxy)-propyl-2-oxymethyl]-purine, its utilization and medicaments containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-12-05 | — | — | EP | disclosed |