Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.42 |
| ▸ | PPARD | Q03181 | 14/20 | 0.42 |
| ▸ | PPARA | Q07869 | 14/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827198 | 0.87 | POLB (0.41) | PPARGPPARDPPARA | |
| SCHEMBL440743 | 0.69 | ALDH1A1 (0.42) | NPC1 | |
| SCHEMBL10515427 | 0.68 | ALDH1A1 (0.38) | PPARGPPARDPPARA | |
| SCHEMBL14020895 | 0.66 | ALDH1A1 (0.42) | PPARGPPARDPPARAPTGS1NPC1 | |
| SCHEMBL14020932 | 0.66 | CYP1A2 (0.50) | PPARGPPARDPPARAPTGS1NPC1 | |
| SCHEMBL8228251 | 0.66 | HTT (0.33) | NPC1 | |
| SCHEMBL14020934 | 0.64 | ALDH1A1 (0.45) | PPARGPPARDPPARA | |
| SCHEMBL9827091 | 0.64 | POLB (0.50) | PTGS1NPC1 | |
| SCHEMBL10511182 | 0.64 | CYP17A1 (0.40) | PPARGPPARDPPARA | |
| SCHEMBL9828053 | 0.62 | ALOX15 (0.45) | PPARGPPARDPPARAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62111990-A | — | — | None | — | — | JP | disclosed |
| EP-0197533-B1 | DIOXOLOBENZISOXAZOLE DERIVATIVES AND PROCESS FOR PREPARING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4732906-A | DIURETICS, HYPOTENSIVES, HYPERURICEMIA | CHUGAI SEIYAKI KABUSHIKI KAISHA (JP) | 1988-03-22 | — | — | US | disclosed |
| JP-S62111990-A | DIOXOLOBENZOISOXAZOLE DERIVATIVE | CHUGAI PHARMACEUT CO LTD | 1987-05-22 | — | — | JP | disclosed |
| EP-0197533-A2 | Dioxolobenzisoxazole derivatives and process for preparing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-10-15 | — | — | EP | disclosed |