Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094131 | 0.87 | EGFR (0.64) | FLT4KDREGFRFGFR1ENPP1 | |
| SCHEMBL11242909 | 0.86 | P2RX7 (0.48) | P2RX7HDAC6POLB | |
| SCHEMBL9369791 | 0.85 | HDAC1 (0.48) | HDAC6 | |
| SCHEMBL11729464 | 0.84 | HDAC1 (0.48) | HDAC6 | |
| SCHEMBL7448126 | 0.82 | MEN1 (0.53) | P2RX7HDAC6FDPSFGFR1FGFR4 | |
| SCHEMBL11281534 | 0.81 | FBP1 (0.40) | P2RX7KDREGFR | |
| SCHEMBL8188011 | 0.78 | P2RX7 (0.47) | P2RX7HDAC6FLT4KDREGFR | |
| SCHEMBL8173334 | 0.77 | P2RX7 (0.44) | P2RX7HDAC6FLT4KDREGFR | |
| SCHEMBL8173320 | 0.77 | P2RX7 (0.44) | P2RX7HDAC6FLT4KDREGFR | |
| SCHEMBL8173326 | 0.77 | P2RX7 (0.44) | P2RX7HDAC6FLT4KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0212535-B1 | N6-DISUBSTITUTED PURINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1991-05-29 | — | — | EP | disclosed |
| US-4853386-A | INHIBITORS OF SRS-A(SLOW REACTING SUBSTANCE OF ANAPHYLAXIS) FROM LUNG TISSUES | BOEHRINGER MANNHEIM GMBH (DE) | 1989-08-01 | — | — | US | disclosed |
| EP-0212535-A1 | N6-disubstituted purine derivatives, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1987-03-04 | — | — | EP | disclosed |
| US-4360522-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4323573-A | VIRICIDES | BURROUGHS WELLCOME CO. (US) | 1982-04-06 | — | — | US | disclosed |
| US-4294831-A | ANTIVIRAL ACTIVITY | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4287188-A | PARTICULARLY 9-(2-HYDROXYETHOXYMETHYL) GUANINE MONOPHOSPHATE AND SALTS, USEFUL AS ANTIVIRIAL AGENTS | BURROUGHS WELLCOME CO. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4199574-A | Methods and compositions for treating viral infections and guanine acyclic nucleosides | BURROUGHS WELLCOME CO. (US) | 1980-04-22 | — | — | US | disclosed |
| US-4146715-A | ANTIVIRAL AGENTS | BURROUGHS WELLCOME CO. (US) | 1979-03-27 | — | — | US | disclosed |