Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | POLG | P54098 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426305 | 0.86 | MEN1 (0.54) | MEN1KMT2ATSHRP2RX7FGFR1 | |
| SCHEMBL9426463 | 0.85 | ENPP1 (0.61) | MEN1KMT2ATSHRFGFR1ENPP1 | |
| SCHEMBL10582443 | 0.85 | TSHR (0.53) | MEN1KMT2ATSHRP2RX7FGFR1 | |
| SCHEMBL11244724 | 0.84 | MEN1 (0.57) | MEN1KMT2ATSHRP2RX7HDAC6 | |
| SCHEMBL9366819 | 0.83 | MEN1 (0.56) | MEN1KMT2ATSHRHDAC6MAPK1 | |
| SCHEMBL9828030 | 0.82 | P2RX7 (0.52) | P2RX7FDPSFGFR1FGFR4HDAC6 | |
| SCHEMBL11252899 | 0.81 | FDPS (0.49) | MEN1KMT2ATSHRP2RX7FDPS | |
| SCHEMBL10563489 | 0.81 | FDPS (0.50) | TSHRP2RX7FDPSFGFR1FGFR4 | |
| SCHEMBL9366802 | 0.79 | MEN1 (0.63) | MEN1KMT2ATSHRP2RX7HDAC6 | |
| SCHEMBL357273 | 0.79 | FDPS (0.45) | P2RX7FDPSFGFR1FGFR4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565566-A | N6-(ENDO(1R,2S,4S)-2-NORBORNYL)-9-METHYLADENINE OR N6-(ENDO(1S,2R,4R)-2-NORBORNYL)-9-METHYLADENINE | DISCOVERY THERAPEUTICS, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5256398-A | Mixture of adenosine, or an adenosine antagonist, with an adenosine receptor | WHITBY RESEARCH, INC. (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0457773-A4 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | — | 1993-03-10 | — | — | EP | disclosed |
| US-5117830-A | Dilating the vascular system with adenosine; labeling; supplying a adenosine recetor antagonist | WHITBY RESEARCH, INC. (US) | 1992-06-02 | — | — | US | disclosed |
| EP-0457773-A1 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, Inc. (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009178-A1 | N6-SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, INC. (US) | 1990-08-23 | — | — | WO | disclosed |
| EP-0306845-A2 | Medicinal preparation containing certain derivatives of 6-mercaptopurine, use of these derivatives of 6-mercaptopurine, process for the preparation of the medicinal preparation and some derivatives of 6-mercaptopurine and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-03-15 | — | — | EP | disclosed |