SCHEMBL9828236

SCHEMBL9828236

COC(=O)C(C)Oc1cc(Oc2ncc(C(F)(F)F)cc2Cl)ccc1C=O

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.53
PPARG P37231 6/20 0.50
SMN1; SMN2 Q16637 4/20 0.50
LIPE Q05469 1/20 0.50
ALDH1A1 P00352 1/20 0.50
MAPK1 P28482 1/20 0.48
RAB9A P51151 1/20 0.47
KMT2A Q03164 2/20 0.47
ATM Q13315 1/20 0.47
FFAR1 O14842 1/20 0.47
MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9826529 0.86 LIPE (0.49) LMNAPPARGSMN1; SMN2LIPEALDH1A1
SCHEMBL9847155 0.86 LIPE (0.49) LMNAPPARGSMN1; SMN2LIPEALDH1A1
SCHEMBL10573318 0.86 LMNA (0.56) LMNAPPARGSMN1; SMN2LIPEALDH1A1
Haloxyfop-P-Methyl SCHEMBL54547 0.85 LMNA (0.65) LMNASMN1; SMN2LIPEALDH1A1MAPK1
Haloxyfop-P-Methyl SCHEMBL29370417 0.85 LMNA (0.65) LMNASMN1; SMN2LIPEALDH1A1MAPK1
Haloxyfop-P-Methyl SCHEMBL54814 0.85 LMNA (0.65) LMNASMN1; SMN2LIPEALDH1A1MAPK1
Haloxyfop-P-Methyl SCHEMBL29514646 0.85 LMNA (0.65) LMNASMN1; SMN2LIPEALDH1A1MAPK1
SCHEMBL7935274 0.85 LMNA (0.55) LMNASMN1; SMN2LIPEALDH1A1RAB9A
SCHEMBL9826940 0.85 FFAR1 (0.47) PPARGMAPK1KMT2AFFAR1MEN1
SCHEMBL9572468 0.84 LMNA (0.52) LMNAPPARGSMN1; SMN2LIPEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0442172-A1 Oxime derivatives and Herbicides containing the same as an active ingredient TEIJIN LIMITED (JP) 1991-08-21 EP disclosed
EP-0433451-A1 OXIME DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS AN ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1991-06-26 EP disclosed
WO-1990001874-A1 OXIME DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS AN ACTIVE INGREDIENT TEIJIN LIMITED (JP) 1990-03-08 WO disclosed