Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7262324 | 0.84 | MGAM (0.38) | SMN1; SMN2TSHRALDH1A1KDM4EGAA | |
| SCHEMBL18065659 | 0.81 | MMP8 (0.53) | SMN1; SMN2L3MBTL1TSHRMMP8ALDH1A1 | |
| SCHEMBL4849811 | 0.80 | MAOB (0.42) | ALDH1A1CTSLCTSSCTSKMAOB | |
| SCHEMBL28240288 | 0.77 | MMP8 (0.49) | L3MBTL1TSHRMMP8ALDH1A1PPID | |
| SCHEMBL7447177 | 0.76 | MMP8 (0.48) | L3MBTL1TSHRMMP8ALDH1A1PPID | |
| SCHEMBL28767197 | 0.76 | MMP8 (0.48) | SMN1; SMN2L3MBTL1TSHRMMP8ALDH1A1 | |
| SCHEMBL15233366 | 0.75 | MGAM (0.43) | SMN1; SMN2TSHRALDH1A1KDM4EGAA | |
| SCHEMBL7515035 | 0.73 | MAOB (0.42) | TSHRCTSSCTSKMAOBTDP1 | |
| SCHEMBL1762807 | 0.72 | MGAM (0.38) | SMN1; SMN2TSHRALDH1A1GAATDP1 | |
| SCHEMBL12268225 | 0.71 | TRPA1 (0.53) | L3MBTL1TSHRMMP8ALDH1A1PPID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |