Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29449720 | 0.88 | MAPT (0.53) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL16763481 | 0.83 | SLC18A3 (0.47) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL1704973 | 0.81 | MAPT (0.56) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL9828015 | 0.80 | CHRNA7 (0.50) | CHKAALDH1A1KDM4ETP53LMNA | |
| SCHEMBL10035921 | 0.80 | MAPT (0.49) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL3439981 | 0.80 | CHKA (0.61) | CHKAADRB2NCF1PLD1ALDH1A1 | |
| SCHEMBL241159 | 0.79 | DHFR (0.50) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL5632543 | 0.78 | CHKA (0.46) | CHKAKDM1AMAOBADRB2NCF1 | |
| SCHEMBL20401806 | 0.77 | MAPT (0.46) | SLC18A3ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL9827139 | 0.77 | POLB (0.54) | SLC18A3ALDH1A1MAPTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291210-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1991-11-06 | — | — | EP | disclosed |
| US-4835165-A | Antiarrhythmic 4-phenylpiperidines | PFIZER INC. (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0291210-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-11-17 | — | — | EP | disclosed |