Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498235 | 0.85 | TSHR (0.41) | TSHRBACE1 | |
| SCHEMBL19604178 | 0.83 | TSHR (0.40) | TSHRBACE1 | |
| SCHEMBL16597503 | 0.79 | TSHR (0.48) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL23596518 | 0.79 | TSHR (0.48) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL98976 | 0.79 | TSHR (0.48) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL9402162 | 0.77 | TSHR (0.46) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL9360332 | 0.76 | TSHR (0.44) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL9402143 | 0.76 | TSHR (0.44) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL9467064 | 0.74 | TSHR (0.43) | TSHRBACE1RGS12PTGER3 | |
| SCHEMBL1012467 | 0.72 | KDM4E (0.42) | TSHRBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298583-B1 | AROMATIC THIOETHERS | LILLY INDUSTRIES LIMITED (GB) | 1991-08-21 | — | — | EP | disclosed |
| US-4968711-A | LEUKOTRIENE ANTAGONISTS | LILLY INDUSTRIES LIMITED (GB) | 1990-11-06 | — | — | US | disclosed |
| EP-0298583-A1 | Aromatic thioethers | LILLY INDUSTRIES LIMITED (GB) | 1989-01-11 | — | — | EP | disclosed |