Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.47 |
| ▸ | TUBB | P07437 | 3/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243118 | 0.86 | ACHE (0.52) | ACHEMAPTCYP3A4CA9TUBB4A | |
| SCHEMBL5574091 | 0.86 | TUBB1 (0.51) | ACHETUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL683553 | 0.85 | ACHE (0.54) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL9239785 | 0.84 | ESR1 (0.57) | MAPTCYP3A4PTGS2TUBB4ATUBB | |
| SCHEMBL13580004 | 0.83 | MGAM (0.46) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL12635123 | 0.82 | TUBB1 (0.46) | ACHEMAPTTUBB4ATUBBTUBA3C | |
| Isoerianin SCHEMBL12635121 | 0.82 | TUBB1 (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL12634266 | 0.82 | TUBB1 (0.51) | MAPTCYP3A4TUBB4ATUBBTUBA3C | |
| Isoerianin SCHEMBL30753433 | 0.82 | TUBB1 (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9245685 | 0.82 | TUBB4A (0.55) | MAPTTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199324-B1 | NEW 2,5-DIARYL TETRYHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |