Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.51 |
| ▸ | TUBB | P07437 | 7/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828544 | 0.86 | ACHE (0.54) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9243118 | 0.85 | ACHE (0.52) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL15232928 | 0.84 | CA1 (0.52) | CYP1A2ACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL9239785 | 0.84 | ESR1 (0.57) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11293247 | 0.83 | CA1 (0.57) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL834546 | 0.82 | CA1 (0.61) | CYP1A2GAAACHEMEN1KMT2A | |
| SCHEMBL12574042 | 0.81 | PKM (0.42) | TUBB1CYP1A2ACHEALDH1A1L3MBTL1 | |
| SCHEMBL9245685 | 0.81 | TUBB4A (0.55) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29062481 | 0.80 | ALDH1A1 (0.48) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12634268 | 0.80 | TUBB4A (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573490-A | diaryl-2H-aziridines and diaryl aziridines compounds, preparation method and application thereof | 复旦大学 | 2022-06-03 | — | — | CN | disclosed |
| CN-110526805-A | A kind of fluorine substituted diphenylamine ethane derivative and preparation method and application | SHANGHAI INST TECH | 2019-12-03 | — | — | CN | disclosed |
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENRIFIQUE (CNRS) | 2011-06-30 | — | — | US | disclosed |
| WO-2009147217-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2009-12-10 | — | — | WO | disclosed |
| EP-1802560-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | Arizona Board Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1438281-A4 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | OXIGENE INC (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2006036743-A2 | HALOCOMBSTATINS AND METHODS OF SYNTHESIS THEREOF | ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-1438281-A2 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | Oxigene, Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003035008-A2 | FUNCTIONALIZED STILBENE DERIVATIVES AS IMPROVED VASCULAR TARGETING AGENTS | OXIGENE, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
| EP-0641301-A1 | STILBENE DERIVATIVES AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | TUBB4A, TUBA4A, TUBGCP4 | TUBB1 8/4885TUBB4A 1/4885TUBB 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.