Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30378846 | 1.00 | HSD17B10 (0.60) | HSD17B10IMPDH2MAPK1DYRK1AGSK3B | |
| SCHEMBL31127913 | 0.81 | CLK1 (0.59) | HSD17B10IMPDH2MAPK1DYRK1AGSK3B | |
| SCHEMBL11258541 | 0.81 | CLK1 (0.59) | HSD17B10IMPDH2MAPK1DYRK1AGSK3B | |
| SCHEMBL8939433 | 0.79 | CDK9 (0.62) | DYRK1AGSK3BCDK5CDK5R1FLT3 | |
| SCHEMBL29869196 | 0.79 | CDK9 (0.62) | DYRK1AGSK3BCDK5CDK5R1FLT3 | |
| SCHEMBL29511348 | 0.78 | MEN1 (0.57) | IMPDH2DYRK1AGSK3BCDK5CDK5R1 | |
| SCHEMBL30179146 | 0.78 | MEN1 (0.57) | IMPDH2DYRK1AGSK3BCDK5CDK5R1 | |
| SCHEMBL1612519 | 0.78 | HTR1A (0.49) | HSD17B10IMPDH2MAPK1DYRK1AGSK3B | |
| SCHEMBL1611705 | 0.78 | CDK5 (0.63) | IMPDH2GSK3BCDK5CDK5R1CLK1 | |
| SCHEMBL15903807 | 0.77 | TDO2 (0.56) | HSD17B10IMPDH2MAPK1DYRK1AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283922-A | Preparation method of 4-indolopyrimidine biaryl compound | 新天地医药技术研究院(郑州)有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-115819406-B | Synthesis method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-06-02 | — | — | CN | claimed |
| CN-115819406-A | Synthetic method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-113582976-B | Deuterated 2-substituted aniline-4-indolyl pyrimidine derivative and preparation method and application thereof | 郑州大学 | 2023-03-17 | — | — | CN | claimed |
| CN-116283922-A | Preparation method of 4-indolopyrimidine biaryl compound | 新天地医药技术研究院(郑州)有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116283922-A | Preparation method of 4-indolopyrimidine biaryl compound | 新天地医药技术研究院(郑州)有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-115819406-B | Synthesis method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115819406-B | Synthesis method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115819406-B | Synthesis method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-06-02 | — | — | CN | disclosed |
| CN-115819406-A | Synthetic method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115819406-A | Synthetic method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-115819406-A | Synthetic method of 3- (4-pyrimidine) -1H-indole compound | 淄博百极荣创医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109328059-B | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-110229142-A | The inhibitor of cell cycle protein dependent kinase 7 (CDK7) | 希洛斯医药品股份有限公司 | 2019-09-13 | — | — | CN | disclosed |
| CN-106458990-B | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-104761544-B | The selective depressant of the important mutant of clinic of EGFR tyrosine kinase | 北京轩义医药科技有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-109328059-A | Selective inhibitors of clinically important mutants of EGFR tyrosine kinase | CS制药技术有限公司 | 2019-02-12 | — | — | CN | disclosed |
| CN-106458990-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-103153982-A | 4-(1H-Indol-3-yl) -pyrimidines as ALK inhibitors | ASTRAZENECA AB | 2013-06-12 | — | — | CN | disclosed |
| EP-0422178-A1 | PYRIMIDINE DERIVATIVES. | ICI PLC (GB) | 1991-04-17 | — | — | EP | disclosed |