Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099585 | 1.00 | MAPK1 (0.69) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL12999515 | 0.88 | CA1 (0.51) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL10099596 | 0.84 | L3MBTL1 (0.61) | MAPK1KDM4EALDH1A1SMN1; SMN2CA2 | |
| SCHEMBL428355 | 0.83 | MAPK1 (1.00) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL13286818 | 0.83 | KDM4E (0.53) | POLBKDM4ELMNASMN1; SMN2 | |
| SCHEMBL8031999 | 0.82 | MAPK1 (0.64) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL21597883 | 0.81 | MAPK1 (0.62) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL31711018 | 0.81 | KDM4E (0.45) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL31710886 | 0.81 | KDM4E (0.45) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 | |
| SCHEMBL27144051 | 0.81 | KDM4E (0.45) | MAPK1CYP1A2CYP2C9CYP2C19HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |