Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.75 |
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.60 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27389992 | 0.93 | PTGS2 (0.75) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL11684110 | 0.88 | MEN1 (0.64) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL425101 | 0.86 | PTGS2 (1.00) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL9785877 | 0.85 | PTGS2 (0.81) | PTGS2GAAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9017504 | 0.84 | PTGS2 (0.96) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL4893276 | 0.83 | ALDH1A1 (0.66) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL7143357 | 0.82 | GAA (0.65) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL4897180 | 0.81 | PTGS2 (0.75) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL7040726 | 0.81 | PTGS2 (1.00) | PTGS2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL11783307 | 0.81 | PTGS2 (0.86) | PTGS2GAAALDH1A1TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119431397-B | Benzotriazine free radical compound, preparation method thereof and application thereof in organic memristors and artificial synapses | ZHENGZHOU UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-119431397-A | Benzotriazine free radical compound, preparation method thereof and application thereof in organic memristors and artificial synapses | 郑州大学 | 2025-02-14 | — | — | CN | disclosed |
| US-9840470-B2 | Targeting GLI proteins in human cancer by small molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-12-12 | — | — | US | disclosed |
| EP-2734042-B1 | TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES | UNIV CALIFORNIA (US) | 2017-02-01 | — | — | EP | disclosed |
| US-9370521-B2 | Targeting GLI proteins in human cancer by small molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150361048-A1 | Targeting Gli Proteins in Human Cancer by Small Molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-12-17 | — | — | US | disclosed |
| US-20140303160-A1 | Targeting GLI Proteins in Human Cancer by Small Molecules | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-10-09 | — | — | US | disclosed |
| WO-2014116651-A1 | TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-31 | — | — | WO | disclosed |
| WO-2013013190-A1 | TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-01-24 | — | — | WO | disclosed |
| EP-0200736-B1 | PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE | SANDOZ AG (CH) | 1991-04-24 | — | — | EP | disclosed |
| EP-0200736-A1 | PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE. | SANDOZ AG (CH) | 1986-11-12 | — | — | EP | disclosed |
| US-4613610-A | TREATING ATHEROSCLEROSIS AND HYPERLIPEMIA | SANDOZ PHARMACEUTICALS CORP. (US) | 1986-09-23 | — | — | US | disclosed |
| WO-1986000307-A2 | PYRAZOLE ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE | SANDOZ AG (CH) | 1986-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303160-A1 | Targeting GLI Proteins in Human Cancer by Small Molecules | GLI2, GLI1, MYC | PTGS2 2872/4885GAA 2275/4885ALDH1A1 2881/4885 |
| US-20150361048-A1 | Targeting Gli Proteins in Human Cancer by Small Molecules | GLI2, GLI1, MYC | PTGS2 2872/4885GAA 2275/4885ALDH1A1 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.