Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829781 | 0.88 | TOP2A (0.51) | TOP2ACYP4F2CYP4A11ALDH1A1LTA4H | |
| SCHEMBL31393686 | 0.86 | TOP2A (0.52) | TOP2ACYP4F2CYP4A11ALDH1A1MAPT | |
| SCHEMBL29136436 | 0.86 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2MAPTHPGDKMT2A | |
| SCHEMBL9445986 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TDP1SMN1; SMN2MAPTHPGD | |
| SCHEMBL9830404 | 0.84 | MAPT (0.56) | TOP2ACYP4F2CYP4A11ALDH1A1SMN1; SMN2 | |
| SCHEMBL22074033 | 0.83 | TOP2A (0.43) | TOP2ACYP4F2CYP4A11ALDH1A1LTA4H | |
| SCHEMBL9831315 | 0.82 | APEX1 (0.47) | TOP2ACYP4F2CYP4A11ALDH1A1MAPT | |
| SCHEMBL9831144 | 0.82 | APEX1 (0.47) | TOP2AALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL8115908 | 0.82 | TOP2A (0.51) | TOP2ACYP4F2CYP4A11ALDH1A1LTA4H | |
| SCHEMBL9832645 | 0.82 | GAA (0.56) | TOP2AALDH1A1L3MBTL1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |