Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10805715 | 0.90 | MEN1 (0.50) | MEN1KMT2AL3MBTL1GAALMNA | |
| SCHEMBL9830621 | 0.82 | MAOB (0.52) | L3MBTL1MAOBLMNADPP4 | |
| SCHEMBL21221367 | 0.81 | MAOB (0.47) | MAOB | |
| SCHEMBL9828629 | 0.79 | ADRB1 (0.51) | MAOB | |
| SCHEMBL9829593 | 0.76 | KCNK3 (0.40) | KMT2AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL9829916 | 0.74 | ALDH1A1 (0.55) | MEN1KMT2AL3MBTL1GAALMNA | |
| SCHEMBL9832439 | 0.73 | KDM4E (0.44) | MEN1KMT2AGAALMNA | |
| SCHEMBL9829266 | 0.73 | CA9 (0.60) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL5014367 | 0.73 | PDE4B (0.56) | — | |
| SCHEMBL10407582 | 0.73 | ALDH1A1 (0.46) | KMT2AL3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |