Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690612 | 0.89 | ADRB1 (0.59) | ADRB1POLBALDH1A1ALOX5PRKDC | |
| SCHEMBL9829333 | 0.86 | POLB (0.53) | ADRB1MAOBPOLBALDH1A1MAPT | |
| SCHEMBL9831116 | 0.85 | ADRB1 (0.55) | ADRB1MAOBPOLBALOX5MAPT | |
| SCHEMBL17893823 | 0.79 | ADRB1 (0.49) | ADRB1POLBALDH1A1PRKDCMAPT | |
| SCHEMBL9829549 | 0.79 | MEN1 (0.48) | MAOB | |
| SCHEMBL9830621 | 0.78 | MAOB (0.52) | MAOBPOLBALDH1A1MAPT | |
| SCHEMBL19545461 | 0.78 | L3MBTL1 (0.49) | ADRB1POLBALDH1A1MAPTTSHR | |
| SCHEMBL17902043 | 0.78 | ADRB1 (0.47) | ADRB1MAOBPOLBALDH1A1ALOX5 | |
| SCHEMBL17893775 | 0.78 | ADRB1 (0.47) | ADRB1MAOBPOLBALDH1A1PRKDC | |
| SCHEMBL17893590 | 0.78 | ADRB1 (0.51) | ADRB1MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |