Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830326 | 0.88 | NR3C2 (0.54) | KDM4ENR3C2BACE1TAAR1DAO | |
| SCHEMBL10749832 | 0.84 | KDM4E (0.62) | KDM4EMAPTCYP1A2L3MBTL1ALDH1A1 | |
| SCHEMBL4452291 | 0.83 | BACE1 (0.62) | KDM4EMAPTCYP1A2KDM4CNR4A2 | |
| SCHEMBL13962897 | 0.83 | KDM4E (0.51) | KDM4EMAPTCYP1A2NR3C2KDM5B | |
| Hydrochloric Acid SCHEMBL4603331 | 0.82 | BACE1 (0.60) | KDM4EMAPTCYP1A2KDM4CNR4A2 | |
| SCHEMBL10571227 | 0.81 | ANO1 (0.51) | KDM4EMAPTCYP1A2NR3C2KMT2A | |
| SCHEMBL4039152 | 0.78 | NR3C2 (0.49) | KDM4EMAPTNR3C2KDM4CKDM5A | |
| SCHEMBL8884069 | 0.77 | NR4A2 (0.56) | KDM5AKDM5BNR4A2KMT2AL3MBTL1 | |
| SCHEMBL14358101 | 0.74 | KDM4E (0.66) | KDM4EMAPTCYP1A2KMT2AL3MBTL1 | |
| SCHEMBL9832962 | 0.73 | HSD11B1 (0.45) | KDM4ECYP1A2NR3C2KMT2AHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208855-B1 | PROCESS FOR PREPARING PIPERIDYLIDENE DIHYDRODIBENZO(A,D)CYCLOHEPTENES AND AZA DERIVATIVES THEREOF, COMPOUNDS OBTAINED BY SUCH PROCESS AND THE USE OF SUCH COMPOUNDS FOR PREPARING USEFUL PHARMACEUTICAL COMPOSITIONS | SCHERING CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4659716-A | Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines | SCHERING CORPORATION (US) | 1987-04-21 | — | — | US | disclosed |
| EP-0208855-A1 | Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions | SCHERING CORPORATION (US) | 1987-01-21 | — | — | EP | disclosed |