Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831831 | 0.74 | KMT2A (0.55) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL10727722 | 0.68 | ABCC8 (0.63) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL8878883 | 0.67 | MAPT (0.72) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL9813147 | 0.67 | MAPT (0.63) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL4266841 | 0.67 | KDM4E (0.56) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL3760039 | 0.66 | CA12 (1.00) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL29766352 | 0.66 | CA12 (1.00) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL9007414 | 0.66 | MAPT (0.70) | KDM4EPOLBMAPTKMT2ACA12 | |
| SCHEMBL9830944 | 0.66 | SNCA (0.61) | KDM4EMAPTKMT2ASRCCCR1 | |
| SCHEMBL7929271 | 0.65 | KDM4E (0.53) | KDM4EPOLBMAPTKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0140709-B1 | 5-LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-04-03 | — | — | EP | disclosed |
| US-4634766-A | LIPOXYGENASE INHIBITORS | MERCK FROSST CANADA, INC. (CA) | 1987-01-06 | — | — | US | disclosed |
| EP-0140709-A2 | 5-Lipoxygenase inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-05-08 | — | — | EP | disclosed |