Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.63 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829645 | 0.82 | CA2 (0.55) | CA2CA1CALM1CA12 | |
| SCHEMBL10373236 | 0.81 | CA2 (0.56) | CA2CA1LOXCA12 | |
| SCHEMBL9828407 | 0.79 | CA2 (0.60) | CA2LOX | |
| SCHEMBL10372094 | 0.78 | CA2 (1.00) | CA2LOX | |
| SCHEMBL10372360 | 0.74 | CA2 (1.00) | CA2CA1LOXCA12CA7 | |
| Sulfuric Acid SCHEMBL10850211 | 0.73 | CA2 (0.88) | CA2LOX | |
| SCHEMBL5150971 | 0.70 | MGLL (0.59) | CA2MGLLSLC28A3IGF1RALOX15 | |
| SCHEMBL10371658 | 0.70 | CA2 (1.00) | CA2CA1LOXCA12CA7 | |
| SCHEMBL9831469 | 0.69 | CA2 (0.63) | CA2CA1LOXCA12CA7 | |
| SCHEMBL9768512 | 0.69 | MGLL (0.50) | CA2MGLLIGF1RALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |