Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880107 | 0.86 | L3MBTL1 (0.46) | TOP2AALDH1A1MAPTBCL6BCOR | |
| SCHEMBL3037330 | 0.85 | ALDH1A1 (0.50) | TOP2AALDH1A1MAPTBCL6BCOR | |
| SCHEMBL27943015 | 0.82 | MAPT (0.58) | ALDH1A1MAPTALOX15 | |
| SCHEMBL9830011 | 0.82 | L3MBTL1 (0.43) | ALDH1A1MAPTL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL16302283 | 0.82 | TOP2A (0.48) | TOP2AALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL4865806 | 0.82 | TOP2A (0.48) | TOP2AALDH1A1MAPTNLRP3MGAM | |
| SCHEMBL9830975 | 0.81 | TOP2A (0.47) | TOP2AALDH1A1MAPTL3MBTL1CYP1A2 | |
| SCHEMBL9832154 | 0.79 | CYP1A2 (0.46) | TOP2AALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL658049 | 0.79 | MAPT (0.59) | TOP2AALDH1A1MAPTL3MBTL1GAA | |
| SCHEMBL9830974 | 0.79 | TOP2A (0.46) | TOP2AALDH1A1MAPTCYP1A2NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |