Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831770 | 0.92 | PPARG (0.50) | PLA2G2ABLMSMN1; SMN2PPARGALDH1A1 | |
| SCHEMBL10688503 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARGALDH1A1HPGDNPC1 | |
| SCHEMBL9832657 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2PPARGALOX15KDM4EMAPT | |
| SCHEMBL9829986 | 0.87 | ALDH1A1 (0.52) | SMN1; SMN2PPARGALDH1A1HPGDGAA | |
| SCHEMBL9831883 | 0.85 | SMN1; SMN2 (0.44) | PLA2G2ABLMSMN1; SMN2PPARGGAA | |
| SCHEMBL9829491 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2PPARGALDH1A1KDM4EMEN1 | |
| SCHEMBL10407589 | 0.82 | SMN1; SMN2 (0.43) | PLA2G2ABLMSMN1; SMN2PPARGALDH1A1 | |
| SCHEMBL9829939 | 0.82 | SMN1; SMN2 (0.43) | PLA2G2ABLMSMN1; SMN2PPARGALDH1A1 | |
| SCHEMBL10407235 | 0.82 | SMN1; SMN2 (0.43) | PLA2G2ABLMSMN1; SMN2PPARGHPGD | |
| SCHEMBL9829977 | 0.81 | SMN1; SMN2 (0.42) | PLA2G2ABLMSMN1; SMN2PPARGHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |