Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9349279 | 0.91 | MTNR1A (0.53) | SMN1; SMN2MTNR1AMTNR1BPPARGALOX15 | |
| SCHEMBL9830144 | 0.87 | PLA2G2A (0.46) | SMN1; SMN2PPARGALOX15HTTKDM4E | |
| SCHEMBL9829514 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTMAPT | |
| SCHEMBL10407520 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPT | |
| SCHEMBL9832157 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2PPARG | |
| SCHEMBL10407247 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTMAPT | |
| SCHEMBL9829491 | 0.84 | ALDH1A1 (0.43) | SMN1; SMN2PPARGHTTKDM4E | |
| SCHEMBL10408081 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2MTNR1AMTNR1BPPARGKDM4E | |
| SCHEMBL10394460 | 0.83 | MTNR1A (0.47) | SMN1; SMN2MTNR1AMTNR1BALOX15HTT | |
| SCHEMBL342248 | 0.83 | LMNA (0.54) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |