Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829393 | 0.86 | CA2 (0.44) | CA2CA12CA1CA9 | |
| SCHEMBL9829756 | 0.81 | CA2 (0.48) | CA2 | |
| SCHEMBL10387588 | 0.79 | C1S (0.38) | CA2 | |
| SCHEMBL9830133 | 0.75 | CA2 (0.49) | CA2CA12CA1CA9 | |
| SCHEMBL10388515 | 0.69 | CA2 (0.39) | CA2 | |
| SCHEMBL5173252 | 0.68 | CA2 (0.51) | CA2NR1H2CA12CA1CA9 | |
| SCHEMBL10388257 | 0.68 | CA2 (0.38) | CA2 | |
| SCHEMBL10387650 | 0.66 | CA2 (0.40) | CA2 | |
| SCHEMBL9828441 | 0.66 | CA2 (0.50) | CA2CA12CA1CA9 | |
| SCHEMBL10389344 | 0.65 | CA2 (0.36) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |