Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26448103 | 0.97 | CHRNB2 (0.44) | CHRNB2CHRNA4CHKATERTALDH1A1 | |
| SCHEMBL18278244 | 0.84 | CHRNB2 (0.40) | CHRNB2CHRNA4CHKAALDH1A1MAPT | |
| SCHEMBL2278389 | 0.84 | KMT2A (0.41) | CHRNB2CHRNA4CHKAALDH1A1MAPT | |
| SCHEMBL24269907 | 0.84 | ALDH1A1 (0.45) | CHRNB2CHRNA4CHKATERTALDH1A1 | |
| SCHEMBL12496993 | 0.84 | CHRNB2 (0.40) | CHRNB2CHRNA4CHKATERTALDH1A1 | |
| SCHEMBL15094990 | 0.83 | MAPT (0.41) | CHRNB2CHRNA4TERTALDH1A1MAPT | |
| SCHEMBL24269959 | 0.81 | KDM4E (0.44) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL29346310 | 0.80 | CHRNB2 (0.40) | CHRNB2CHRNA4ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL24270110 | 0.80 | CHRNB2 (0.37) | CHRNB2CHRNA4CHKATERTALDH1A1 | |
| SCHEMBL3759138 | 0.80 | DRD2 (0.41) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |