Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831566 | 0.92 | NLRP3 (0.44) | SMN1; SMN2NLRP3TSHRALDH1A1HSD17B10 | |
| SCHEMBL9830274 | 0.90 | SMN1; SMN2 (0.44) | SMN1; SMN2NLRP3TSHRALDH1A1HSD17B10 | |
| SCHEMBL9829742 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4EALOX5LTA4H | |
| SCHEMBL9830935 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2NLRP3ALDH1A1HSD17B10MAPT | |
| SCHEMBL9832361 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2NLRP3ALDH1A1MAPTKDM4E | |
| SCHEMBL9831771 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRALDH1A1HSD17B10MAPT | |
| SCHEMBL9832038 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1HSD17B10MAPTKDM4E | |
| SCHEMBL2502597 | 0.80 | NLRP3 (0.43) | SMN1; SMN2NLRP3TSHRALDH1A1HSD17B10 | |
| SCHEMBL9831853 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2NLRP3TSHRALDH1A1MAPT | |
| SCHEMBL9829514 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1HSD17B10MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |