Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830274 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2NLRP3MAPTKDM4EGLA | |
| SCHEMBL9831566 | 0.89 | NLRP3 (0.44) | SMN1; SMN2NLRP3MAPTKDM4EGLA | |
| SCHEMBL9832188 | 0.82 | NLRP3 (0.43) | SMN1; SMN2NLRP3KDM4EHPGDALDH1A1 | |
| SCHEMBL9830346 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2NLRP3MAPTKDM4EGLA | |
| SCHEMBL9831675 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2MAPTHPGDALDH1A1CYP4F2 | |
| SCHEMBL9829450 | 0.78 | NLRP3 (0.43) | SMN1; SMN2NLRP3MAPTALDH1A1HSD17B10 | |
| SCHEMBL14161430 | 0.77 | TDP1 (0.53) | SMN1; SMN2NLRP3KDM4EHPGDALDH1A1 | |
| SCHEMBL142890 | 0.77 | ALOX5 (0.39) | SMN1; SMN2NLRP3MAPTKDM4EGLA | |
| SCHEMBL20836328 | 0.77 | ALDH1A1 (0.42) | SMN1; SMN2MAPTALDH1A1HSD17B10KMT2A | |
| SCHEMBL9829879 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2NLRP3CYP4F2CYP4A11CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |