Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831029 | 0.91 | KDM4E (0.60) | MAPTKDM4ETSHRALDH1A1TACR1 | |
| SCHEMBL10408283 | 0.85 | POLB (0.55) | MAPTKDM4ETSHRHSP90AB1ALDH1A1 | |
| SCHEMBL9831681 | 0.84 | MEN1 (0.49) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL9832290 | 0.81 | ABCB1 (0.50) | KDM4ETSHRMEN1KMT2APOLB | |
| SCHEMBL10408096 | 0.81 | KDM4E (0.53) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL9832675 | 0.80 | SIGMAR1 (0.54) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9832337 | 0.79 | KMT2A (0.43) | MAPTKDM4ETP53MEN1KMT2A | |
| SCHEMBL9831214 | 0.79 | KDM4E (0.50) | MAPTKDM4ETSHRALDH1A1TACR1 | |
| SCHEMBL9831615 | 0.77 | TACR1 (0.57) | MAPTKDM4ETSHRNPC1HSP90AB1 | |
| SCHEMBL9833027 | 0.77 | MAPT (0.50) | MAPTKDM4ETSHRALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |