Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LGMN | Q99538 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30464788 | 0.86 | NOTUM (0.67) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL25285181 | 0.86 | NOTUM (0.67) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL9830924 | 0.82 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL9831805 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TSHRKDM4ESMN1; SMN2TDP1 | |
| SCHEMBL3225808 | 0.81 | POLB (0.59) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL9830428 | 0.79 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL17542826 | 0.79 | LGMN (0.59) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL2165481 | 0.77 | ALDH1A1 (0.67) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL6499815 | 0.76 | TSHR (0.66) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN | |
| SCHEMBL13648219 | 0.76 | LGMN (0.65) | ALDH1A1TSHRKDM4ESMN1; SMN2LGMN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |