Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LGMN | Q99538 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831919 | 0.83 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL9831520 | 0.82 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL2767535 | 0.81 | HPGD (0.56) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL9830522 | 0.79 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL25031455 | 0.79 | LGMN (0.56) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL29948657 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL25285181 | 0.76 | NOTUM (0.67) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL17542785 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL30464788 | 0.76 | NOTUM (0.67) | ALDH1A1SMN1; SMN2LGMNTDP1KDM4E | |
| SCHEMBL9831563 | 0.76 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LGMNKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |