Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830224 | 0.88 | MAPT (0.55) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9832167 | 0.85 | MAPT (0.50) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9831799 | 0.84 | MAPT (0.49) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9830345 | 0.84 | NR1H2 (0.41) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4508521 | 0.83 | MAPT (0.52) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL5863292 | 0.80 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL9829081 | 0.79 | ALDH1A1 (0.55) | ALDH1A1MEN1POLBTSHRKMT2A | |
| SCHEMBL9832169 | 0.79 | PDE3B (0.40) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL17893656 | 0.78 | SIRT6 (0.44) | MAPTKDM4EALDH1A1RAB9AMEN1 | |
| SCHEMBL31542266 | 0.77 | MAPT (0.46) | MAPTKDM4EALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |