Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831487 | 0.86 | CYP3A4 (0.47) | NR1H2NR1H3CYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL9831828 | 0.84 | NR1H2 (0.41) | NR1H2NR1H3CYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL9829312 | 0.84 | MAPT (0.43) | NR1H2NR1H3CYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL9830612 | 0.84 | MAPT (0.50) | NR1H2NR1H3KDM4EKMT2APDE3B | |
| SCHEMBL9829593 | 0.83 | KCNK3 (0.40) | NR1H2NR1H3CYP3A4SMN1; SMN2TDP1 | |
| SCHEMBL20098275 | 0.78 | KDM4E (0.50) | SMN1; SMN2KDM4EKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9829081 | 0.77 | ALDH1A1 (0.55) | CYP3A4SMN1; SMN2TDP1KMT2AALDH1A1 | |
| SCHEMBL9832356 | 0.76 | L3MBTL1 (0.54) | SMN1; SMN2KDM4EKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL9830224 | 0.75 | MAPT (0.55) | SMN1; SMN2TDP1KDM4EKMT2APDE3B | |
| SCHEMBL9832167 | 0.73 | MAPT (0.50) | SMN1; SMN2KDM4EKMT2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |