Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | DBH | P09172 | 1/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KRAS | P01116 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109202 | 0.88 | TPMT (0.52) | KDM4EDBHTPMTABCB1ABCC1 | |
| SCHEMBL8109799 | 0.83 | TPMT (0.47) | KDM4EDBHTPMTABCB1ABCC1 | |
| SCHEMBL9829552 | 0.81 | BPTF (0.50) | KDM4EABCB1MEN1KMT2AHTT | |
| SCHEMBL9828773 | 0.79 | KDM4E (0.46) | KDM4EABCB1MEN1KMT2AALDH1A1 | |
| SCHEMBL9829135 | 0.78 | TUBB4A (0.39) | DBHMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL9828901 | 0.77 | ALDH1A1 (0.47) | KDM4EMEN1KMT2AHTTTUBB4A | |
| SCHEMBL9828798 | 0.76 | KDM4E (0.44) | KDM4EABCB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1447632 | 0.76 | TPMT (0.51) | KDM4EDBHTPMTABCB1ABCC1 | |
| SCHEMBL8729017 | 0.75 | TPMT (0.54) | KDM4EDBHTPMTABCB1ABCC1 | |
| SCHEMBL9828028 | 0.75 | MEN1 (0.62) | KDM4ETPMTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199324-B1 | NEW 2,5-DIARYL TETRYHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS | MERCK & CO. INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| EP-0322033-A2 | New 2,5-diaryl tetrahydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0199324-A2 | New 2,5-diaryl tetryhydrofurans and analogs thereof as paf antagonists | MERCK & CO. INC. (US) | 1986-10-29 | — | — | EP | disclosed |