Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 1/20 | 0.38 |
| ▸ | ATP4B | P51164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679707 | 0.85 | SCN9A (0.47) | KAT6APARP1KDM4AKDM4BKDM5C | |
| Methane SCHEMBL27495181 | 0.83 | ALDH1A1 (0.47) | KAT6AKDM4AKDM4BKDM5CKDM5B | |
| Oxamate SCHEMBL9829051 | 0.82 | MEN1 (0.48) | PARP1CHEK2KDM4ECASP1ATP4A | |
| SCHEMBL27732241 | 0.79 | KAT6A (0.49) | KAT6APARP1KDM4AKDM4BKDM5C | |
| SCHEMBL7492735 | 0.78 | KAT6A (0.43) | KAT6APARP1CHEK2KDM4AKDM4B | |
| SCHEMBL7464854 | 0.77 | CHEK2 (0.68) | PARP1CHEK2KDM4AKDM4BKDM5C | |
| Oxamate SCHEMBL9829649 | 0.76 | MAPT (0.44) | KDM4AKDM4BKDM5CKDM5BESR1 | |
| SCHEMBL600911 | 0.75 | KDM4A (0.58) | KAT6APARP1CHEK2KDM4AKDM4B | |
| SCHEMBL4640169 | 0.75 | TSHR (0.59) | KAT6AESR1KDM4EHSD17B10SCN9A | |
| SCHEMBL31018816 | 0.75 | KDM4A (0.67) | KAT6ACHEK2KDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284017-B1 | 4-(3-COUMARINYL)-THIAZOLE-DERIVATIVES WITH ANTI-ALLERGIC, ANTI-ANAPHYLACTIC AND ANTI-ARTHRITIC ACTIVITY AND COMPOSITIONS CONTAINING THEM | ZAMBON GROUP S.p.A. (IT) | 1991-09-11 | — | — | EP | disclosed |
| EP-0190298-B1 | 4-(ISOXAZOLYL)-THIAZOLE-2-OXAMIC ACIDS AND DERIVATIVES THEREOF | ZAMBON S.p.A. (IT) | 1989-10-18 | — | — | EP | disclosed |
| EP-0284017-A1 | 4-(3-coumarinyl)-thiazole-derivatives with anti-allergic, anti-anaphylactic and anti-arthritic activity and compositions containing them | ZAMBON GROUP S.p.A. (IT) | 1988-09-28 | — | — | EP | disclosed |
| US-4766137-A | 4-(isoxazolyl)-thiazole-2-oxamic acids and derivatives thereof | ZAMBON S.P.A. (IT) | 1988-08-23 | — | — | US | disclosed |