Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682855 | 0.82 | LTA4H (0.53) | NPC1KDM4EKIF11TP53ALDH1A1 | |
| SCHEMBL12622638 | 0.80 | KIF11 (0.47) | NPC1RAB9AKDM4EKIF11TNF | |
| SCHEMBL9831572 | 0.79 | SMN1; SMN2 (0.56) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL20390901 | 0.79 | CYP19A1 (0.47) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL15071935 | 0.77 | CDC25A (0.40) | NPC1RAB9AKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL13622940 | 0.76 | RAB9A (0.58) | NPC1RAB9AKDM4ETP53ALDH1A1 | |
| SCHEMBL4899431 | 0.76 | TP53 (0.55) | NPC1RAB9AKDM4ETNFNOD1 | |
| SCHEMBL20390848 | 0.76 | GFER (0.37) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL20390377 | 0.76 | GFER (0.37) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL13145486 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9AKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321115-B1 | CARBOXAMIDE DERIVATIVES HAVING TETRAZOLE AND THIAZOLE RINGS AND THEIR USE | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-14 | — | — | EP | disclosed |
| US-4946855-A | ANTIALLERGIC | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1990-08-07 | — | — | US | disclosed |