Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715055 | 0.98 | ADRB1 (0.66) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL2090991 | 0.83 | ADRB1 (0.54) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8264511 | 0.83 | MAPT (0.68) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL5618735 | 0.83 | MAPT (0.67) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL423400 | 0.81 | MAPT (0.65) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL232689 | 0.81 | ADRB1 (1.00) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9864307 | 0.81 | MAPT (0.65) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8319638 | 0.81 | MAPT (0.65) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1859912 | 0.81 | ADRB1 (0.61) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL23843625 | 0.81 | ABCG2 (0.48) | ADRB1MAPTSMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |