Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CLPP | Q16740 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831957 | 0.84 | COMT (0.46) | CYP2C19KMT2ALMNACOMTMAPT | |
| SCHEMBL9831681 | 0.83 | MEN1 (0.49) | KMT2AACHECOMTKDM4EALDH1A1 | |
| SCHEMBL9832661 | 0.80 | KMT2A (0.52) | KMT2AACHEMAPTKDM4EALDH1A1 | |
| SCHEMBL9832990 | 0.77 | ALDH1A1 (0.45) | KMT2ALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL9831214 | 0.77 | KDM4E (0.50) | KMT2AACHEMAPTKDM4EALDH1A1 | |
| SCHEMBL9830298 | 0.76 | ALDH1A1 (0.45) | KMT2ALMNAACHECLPPMAPT | |
| SCHEMBL14234936 | 0.73 | CYP2C19 (0.67) | CYP2C19KMT2ACYP2A13LMNAACHE | |
| SCHEMBL9829461 | 0.73 | CYP2C19 (0.58) | CYP2C19KMT2ACYP2A13LMNAACHE | |
| SCHEMBL10408283 | 0.73 | POLB (0.55) | KMT2ALMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL14939422 | 0.73 | ALDH1A1 (0.50) | KMT2ACYP2A13LMNAACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |