Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832990 | 0.85 | ALDH1A1 (0.45) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL9830298 | 0.83 | ALDH1A1 (0.45) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL9832290 | 0.81 | ABCB1 (0.50) | KMT2AMEN1KDM4ESIGMAR1USP2 | |
| SCHEMBL9832675 | 0.80 | SIGMAR1 (0.54) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL9831258 | 0.80 | CYP2C19 (0.51) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL29512666 | 0.79 | SIGMAR1 (0.52) | KMT2AMEN1KDM4ESIGMAR1ADORA1 | |
| SCHEMBL5553255 | 0.77 | KMT2A (0.54) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL9831681 | 0.76 | MEN1 (0.49) | KMT2AMEN1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL28817642 | 0.76 | SIGMAR1 (0.48) | KMT2AMEN1SIGMAR1ADORA1PNMT | |
| SCHEMBL28817654 | 0.76 | SIGMAR1 (0.48) | KMT2AMEN1SIGMAR1ADORA1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |