Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LGMN | Q99538 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695436 | 0.85 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2NPSR1LGMNMAPT | |
| SCHEMBL9831520 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TSHRNPSR1LGMN | |
| SCHEMBL9830924 | 0.84 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2TSHRLGMNMAPT | |
| SCHEMBL9829829 | 0.82 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2TSHRLGMNMEN1 | |
| SCHEMBL9831805 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2TSHRNPSR1MAPT | |
| SCHEMBL21533588 | 0.78 | LGMN (0.69) | ALDH1A1SMN1; SMN2LGMNMAPTMEN1 | |
| SCHEMBL31250392 | 0.77 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LGMNMAPTMEN1 | |
| SCHEMBL6501131 | 0.77 | LGMN (0.61) | ALDH1A1SMN1; SMN2TSHRLGMNMAPT | |
| SCHEMBL9831919 | 0.77 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TSHRNPSR1LGMN | |
| SCHEMBL31516231 | 0.76 | GAA (0.62) | ALDH1A1SMN1; SMN2LGMNMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |