Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 6/20 | 0.77 |
| ▸ | RXRA | P19793 | 6/20 | 0.77 |
| ▸ | RARB | P10826 | 5/20 | 0.61 |
| ▸ | RARG | P13631 | 5/20 | 0.61 |
| ▸ | RARA | P10276 | 3/20 | 0.57 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13422461 | 0.87 | RXRB (1.00) | RXRBRXRARARBRARGRARA | |
| SCHEMBL980661 | 0.86 | RARB (0.66) | RXRBRXRARARBRARGRARA | |
| SCHEMBL8900572 | 0.83 | RXRA (0.69) | RXRBRXRARARBRARGRARA | |
| SCHEMBL263623 | 0.82 | PTPN1 (0.58) | RXRBRXRARARBRARGRARA | |
| SCHEMBL2310774 | 0.80 | KMO (0.62) | RXRBRXRARARBRARGRARA | |
| SCHEMBL13900230 | 0.80 | RARB (0.64) | RARBRARGRARALMNAKDM4E | |
| SCHEMBL980736 | 0.80 | DHODH (0.55) | RXRBRXRARARBRARGRARA | |
| SCHEMBL179538 | 0.78 | RXRA (0.66) | RXRBRXRARXRG | |
| SCHEMBL31275978 | 0.78 | CYP26A1 (0.66) | RXRBRXRARARBRARGRXRG | |
| SCHEMBL29049592 | 0.78 | RARB (0.62) | RXRBRXRARARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150098918-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-04-09 | — | — | US | claimed |
| US-20100166852-A1 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | claimed |
| US-20090318550-A1 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-12-24 | — | — | US | claimed |
| US-RE34805-E | Treatment of dermatologic diseases, degeneration of conjunctive tissues; antitumor activity | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1994-12-06 | — | — | US | claimed |
| US-4940696-A | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES (CIRD) (FR) | 1990-07-10 | — | — | US | claimed |
| EP-0199636-B1 | BENZONAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACY AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-02-08 | — | — | EP | claimed |
| US-10925814-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2021-02-23 | — | — | US | disclosed |
| US-10702466-B2 | Emulsions comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-07-07 | — | — | US | disclosed |
| US-20180263865-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-09-20 | — | — | US | disclosed |
| US-9999577-B2 | Cream gels comprising at least one retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2018-06-19 | — | — | US | disclosed |
| EP-3184108-A1 | COMPOSITION COMPRISING A RETINOID AND BENZOYL PEROXIDE | Galderma Research & Development (FR) | 2017-06-28 | — | — | EP | disclosed |
| US-9060948-B2 | Dermatological/cosmetic compositions comprising a retinoid and benzoyl peroxide | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-06-23 | — | — | US | disclosed |
| US-20150098918-A1 | CREAM GELS COMPRISING AT LEAST ONE RETINOID AND BENZOYL PEROXIDE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-04-09 | — | — | US | disclosed |
| US-RE34805-E | Treatment of dermatologic diseases, degeneration of conjunctive tissues; antitumor activity | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1994-12-06 | — | — | US | disclosed |
| US-RE34440-E | Treatment of dermatological diseases and degeneration of conjunctive tissues; antitumor agent | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5212303-A | Benzonaphthalene derivatives, a process for their preparation and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-05-18 | — | — | US | disclosed |
| US-5183889-A | For topical or systemic treatment of dermatologic disease, degeneration of conjunction tissues and tumors | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1993-02-02 | — | — | US | disclosed |
| US-5098895-A | Skin disorders and antitumor agents | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1992-03-24 | — | — | US | disclosed |
| US-4940696-A | Benzonaphthalene derivatives and their use in therapeutic and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIOUES (CIRD) (FR) | 1990-07-10 | — | — | US | disclosed |
| US-4717720-A | DERMATOLOGIC DISEASES, CONJUCTIVE TISSUE DEGENERATION AND ANTI-TUMOR ACTIVITY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1988-01-05 | — | — | US | disclosed |