Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.49 |
| ▸ | PDE4A | P27815 | 10/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 5/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10470996 | 0.99 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9835825 | 0.85 | PDK2 (0.50) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10566029 | 0.85 | ATAD2 (0.39) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9832272 | 0.84 | ALDH1A1 (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9833030 | 0.84 | KDM4E (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9831453 | 0.83 | ATAD2 (0.38) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9832939 | 0.83 | ALDH1A1 (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9829995 | 0.83 | ALDH1A1 (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10373613 | 0.83 | MEN1 (0.44) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10567876 | 0.82 | PDE3B (0.42) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | claimed |
| EP-0161632-B1 | PYRROLO-BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS CONTAINING THEM AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1991-04-10 | — | — | EP | disclosed |
| US-4963686-A | INTERMEDIATES FOR INOTROPIC AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-16 | — | — | US | disclosed |
| US-4863945-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-09-05 | — | — | US | disclosed |
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |