Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831070 | 0.93 | NR1H4 (0.41) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9831514 | 0.91 | MAPT (0.42) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9832636 | 0.91 | LMNA (0.36) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9834162 | 0.90 | CCNA2 (0.40) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9832438 | 0.90 | MAPT (0.45) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9316748 | 0.90 | MAPT (0.44) | CCNA2CDK2CCNA1MAPTPOLB | |
| SCHEMBL9832537 | 0.90 | LMNA (0.42) | RIPK1MAPTPOLBKCNJ6KCNJ3 | |
| SCHEMBL9833530 | 0.90 | RIPK1 (0.41) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9833393 | 0.89 | ALDH1A1 (0.40) | CCNA2CDK2CCNA1RIPK1MAPT | |
| SCHEMBL9834065 | 0.88 | RIPK1 (0.39) | CCNA2CDK2CCNA1RIPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274443-B1 | HETEROARYL 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-05-29 | — | — | EP | disclosed |
| EP-0274443-A1 | Heteroaryl 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-07-13 | — | — | EP | disclosed |