Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832846 | 0.89 | BLM (0.42) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL9833158 | 0.80 | LMNA (0.50) | MEN1KMT2ALMNAPGRGRIA1 | |
| SCHEMBL6904350 | 0.76 | CYP1A2 (0.67) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL612079 | 0.71 | CYP1A2 (1.00) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL6909295 | 0.71 | CYP1A2 (0.65) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL6799574 | 0.71 | CYP1A2 (0.65) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL7063351 | 0.71 | CYP1A2 (0.65) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL29701185 | 0.71 | CYP1A2 (1.00) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL6619480 | 0.70 | SMN1; SMN2 (0.50) | CYP1A2MEN1KMT2ALMNACYP3A4 | |
| SCHEMBL9834896 | 0.68 | PSMB8 (0.45) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257334-B1 | TRICYCLIC BENZOTRIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1991-01-02 | — | — | EP | disclosed |
| US-4835167-A | Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0257334-A2 | Tricyclic benzotriazoles, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |