Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.39 |
| ▸ | PDE2A | O00408 | 4/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9832846 | 0.81 | BLM (0.42) | LMNAPDE3APGRMEN1KMT2A | |
| SCHEMBL9834896 | 0.81 | PSMB8 (0.45) | MEN1KMT2AMAPT | |
| SCHEMBL9832081 | 0.80 | CYP1A2 (0.55) | LMNAPGRMEN1KMT2AGRIA1 | |
| SCHEMBL9677511 | 0.74 | LMNA (0.54) | LMNAPDE3BPDE3APDE2APGR | |
| SCHEMBL9677224 | 0.73 | LMNA (0.53) | LMNAPDE3BPDE3APDE2APGR | |
| SCHEMBL4952422 | 0.69 | AURKA (0.52) | LMNAPDE3BPDE3APDE2AKMT2A | |
| SCHEMBL6651292 | 0.68 | LMNA (0.59) | LMNAPDE3BPDE3APDE2APGR | |
| SCHEMBL15730579 | 0.68 | GRIA1 (0.68) | LMNAPGRMEN1PABPC1KMT2A | |
| SCHEMBL9677526 | 0.68 | LMNA (0.54) | LMNAPDE3BPDE3APDE2APGR | |
| SCHEMBL6619691 | 0.67 | LMNA (0.49) | LMNAPDE3BPDE3APDE2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257334-B1 | TRICYCLIC BENZOTRIAZOLES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1991-01-02 | — | — | EP | disclosed |
| US-4835167-A | Tricyclic benzotriazoles, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1989-05-30 | — | — | US | disclosed |
| EP-0257334-A2 | Tricyclic benzotriazoles, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1988-03-02 | — | — | EP | disclosed |