Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831337 | 0.87 | CHRM2 (0.42) | CHRM2CHRM1CHRM3CHRM4RIPK1 | |
| SCHEMBL2652613 | 0.78 | CHRM2 (0.41) | CHRM2CHRM1CHRM3CHRM4RIPK1 | |
| SCHEMBL9833154 | 0.78 | MET (0.40) | CHRM2CHRM1CHRM3CHRM4KDM4E | |
| SCHEMBL9832437 | 0.77 | CHRM2 (0.40) | CHRM2CHRM1CHRM3CHRM4RIPK1 | |
| SCHEMBL27843753 | 0.75 | NR1H2 (0.55) | CHRM2CHRM1CHRM3CHRM4NR1H2 | |
| SCHEMBL9832449 | 0.73 | CHRM2 (0.38) | CHRM2CHRM1CHRM3CHRM4RIPK1 | |
| SCHEMBL9832277 | 0.73 | TSHR (0.41) | CHRM2CHRM1CHRM3CHRM4RIPK1 | |
| SCHEMBL4636677 | 0.73 | CHRM3 (0.48) | CHRM2CHRM1CHRM3CHRM4KDM4E | |
| SCHEMBL7374418 | 0.73 | NPSR1 (0.41) | CHRM2CHRM1CHRM3CHRM4KDM4E | |
| SCHEMBL826276 | 0.73 | CHRM3 (0.49) | CHRM2CHRM1CHRM3CHRM4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297782-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-05-22 | — | — | EP | disclosed |
| US-4857543-A | TREATMENT OF GASTROINTESTINAL DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0297782-A1 | A thiophene derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1989-01-04 | — | — | EP | disclosed |